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Reproductive toxicity study with a novel deoxyguanosine analogue (Metacavir) in pregnant SD rats
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《医学前沿（英文）》 2015年 第9卷 第1期 页码 82-89 doi: 10.1007/s11684-015-0376-0
Our preliminary studies demonstrated that Metacavir has potential to become a new anti-HBV agent. The main targets of the toxic effects of Metacavir, in rhesus monkeys, were gastrointestinal tracts, liver, blood, and kidneys, which were not related to mitochondrial effects. In this study, the maternal toxicity, embryo-fetal developmental toxicity and teratogenicity were studied in pregnant Sprague-Dawley rats after intragastric administration of Metacavir (200, 100, 50, 0 mg/kg body weight) during the first 6–15 days of pregnancy. Slower weight gain was observed in 5 out of 21 rats subjected to a 200 mg/kg dose, as well as 2 out of 20 subjected to a 100 mg/kg dose. Compared with the solvent control group, the calibration weight gain in the 200 mg/kg and 100 mg/kg dosage groups respectively, during first 6–20 pregnant days were significantly different (P<0.01, P<0.05). Significant dose related adverse effects to other reproductive parameters were not seen in F0 and F1, but the number of stillbirths in high dose group showed notably difference compared with the control group (P<0.05), while the litter incidence showed no difference. No Metacavir-associated pathological changes were observed. The present research indicated that at a dose of 200 mg/(kg·d) (i.e., 40 times the effective dose in rats), Metacavir shows some maternal toxicity to SD rats. The embryotoxicity in the 200 mg/kg group encompass decreased fetal body weight, and higher fetal mortality rates, compared with the control group. However, the litter incidence showed no statistical difference. All the treated rats displayed normal bone development, no teratogenicity and without adverse effects on fetal development, thus indicating that below a dose of 200 mg/(kg·d) there is no teratogenic side effects.
关键词： deoxyguanosine analogue Metacavir pregnancy maternal toxicity embryo toxicity teratogenicity
植物蛋白基仿生肉制品研究进展 Review
孙翠霞, 葛姣, 何君, 甘人友, 方亚鹏
《工程（英文）》 2021年 第7卷 第5期 页码 674-678 doi: 10.1016/j.eng.2020.10.011
蛋白质是人类健康生活必需的营养元素，动物源肉制品是人体补充蛋白质的主要来源。随着全球人口持续增长，人们对蛋白质的需求快速增加，传统畜牧业由于生态环境和动物福利的压力，无法生产足够的肉制品供人类消费。通过一定技术手段制备具有动物肉的纤维结构、质构、颜色、风味、口感、外观的仿生肉制品，充分响应了绿色、环保、健康、可持续发展的理念。本文聚焦植物蛋白基仿生肉制品，重点综述了仿生肉制品的产品配方和制备技术，并基于营养安全角度分析了消费者对仿生肉制品的接受程度。此外，总结了仿生肉制品现阶段发展所面临的主要挑战，并展望了其发展前景。
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Reproductive toxicity study with a novel deoxyguanosine analogue (Metacavir) in pregnant SD rats
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